Thioredoxin-interacting protein-activated intracellular potassium deprivation mediates the anti-tumour effect of a novel histone acetylation inhibitor HL23, a fangchinoline derivative, in human hepatocellular carcinoma

Introduction: Hyperactivated histone deacetylases (HDACs) act as epigenetic repressors on gene transcription and are frequently observed in human hepatocellular carcinoma (HCC).Although multiple pharmacological HDAC inhibitors (HDACis) have been developed, none is available in human HCC.Objectives: To investigate the pharmacological effects of a fa

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Alterations in the Levels of Growth Factors in Adolescents with Major Depressive Disorder: A Longitudinal Study during the Treatment with Fluoxetine

Major depressive disorder (MDD) has a prevalence of 5% in adolescents.Several studies have described the association between the inflammatory response and MDD, but little is known about the relationship between MDD and growth factors, such as IL-7, IL-9, IL-17A, VEGF, basic FGF, G-CSF, and GM-CSF.It must be appointed that there are scarce reports o

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Asymmetric Bimodal Exponential Power Distribution on the Real Line

The asymmetric bimodal exponential power (ABEP) distribution is an extension of the generalized gamma distribution to the real line via adding two parameters that fit roman atwood gfuel the shape of peakedness in bimodality on the real line.The special values of peakedness parameters of the distribution are a combination of half Laplace and half no

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